What is the difference between Pfizer and Moderna vaccines for young children?

Both use the mRNA platform and both are considered safe and well tolerated. Pediatricians say CNN is the two best options to talk about across the country.

“I think they are both very effective and the side effects are very good and I am not afraid to give them to my children either,” the doctor said. Nina Alfieri, Ann of Chicago and Robert H. Luri is a pediatrician at Children’s Hospital. “I think both are good options.”

Both appear to produce protective antibodies in young children, as in young children. There are only subtle differences and one may be better for some children than the other.

The modern Covid-19 vaccine is now approved for children aged 6 months to 5 years. Pfizer for children from 6 months to 4 years.

Pfizer vaccine has previously been approved for children as young as 5 years old. The Modera vaccine was recently approved by the U.S. Food and Drug Administration for people ages 6 to 17, and CDC vaccine consultants will vote on its recommendation this week.

dose and procedure

A child who receives the modern vaccine does not need to go to the doctor or pharmacy more often, and they are protected a little faster than the Pfizer vaccine.

The Moderna series was supplemented with two doses of 25 micrograms given over a period of one month. Children with a weakened immune system get a third shot. Modern bullets for young children make up a quarter of the amount received by adults.

You need three frames to be complete with Pfizer. The company initially tried two doses, but test data showed that the vaccine did not produce a sufficient immune response after the second dose. The three-dose vaccine approved last week is one-tenth of the dose of Pfizer for adults.

The first two shots with Pfizer are given three weeks apart. The third can be given eight weeks after the second. In general, it can take almost three months for a child to have a full series.

Along the way, scientists may want to get boosters with vaccines from two companies for children.

trembling

Children were a little more prone to getting fever with the modern vaccine; If it was less than 10% with Pfizer, it was with a quarter of the test participants. Most of the fevers were mild. Less than 1% of all test participants had a fever of 104 degrees.

“It was rare, but if I’m not honest with my parents, it’s going to be fun when these things come out,” the doctor said. Grant Paulsen is a researcher at the main site of clinical trials of Pfizer and Moderna Covid-19 vaccine for children aged 6 months to 11 years at the Cincinnati Orphanage.
These children lost their young parents to Kovid-19.  Here they want other children and adults to know

“Chances are, most of the kids will be fine and there are really fewer problems,” he said. “Most don’t have big side effects.”

According to Moderna, other diseases that cause fever are circulating during the test, and this may lead to some fevers, as 10.6% of children in the non-vaccinated placebo group developed a fever.

Dr. Claudia Hoyen, a pediatric infectious disease specialist at UH Rainbow Babies Hospital in Cleveland, said she understands why parents hate their child’s fever, but they need to be reassured that the fever doesn’t cause any permanent damage or long-term problems. and should be resolved quickly on its own or in response to over-the-counter medications such as Tylenol or Motrin.

“I think if you keep it.” Yes, it’s scary, but understand that it’s manageable. “ Said Hoyen. “People need to work with pediatricians. I think most children who take their first dose may or may not have a fever, but people need to work with a pediatrician and make a good plan. The best thing is that it needs to be addressed quickly.”

general side effects

Moderna and Pfizer safety data examined by the FDA and the CDC found that potential adverse effects were mostly mild and short-lived.

Children also get Covid for a long time, and it can occur in unexpected ways

Adverse effects of both often included pain at the injection site, and sometimes swelling or redness.

As for systemic or general body symptoms, the most common was fatigue or drowsiness. Some children had irritability or noise, loss of appetite, headache, abdominal pain or discomfort, enlarged lymph nodes, and mild diarrhea or vomiting. But they all recovered quickly.

“It’s very similar to the side effects we’ve seen in older children or adults. Some children are close to 24 hours, you know, they don’t feel well, they’re tired, they’re not like that. But fortunately, these vaccines didn’t have serious side effects,” he said. . Ashish Ja, the White House’s Kovid-19 reaction coordinator, was on CBS on Monday.

The researchers did not see any significant or rare adverse effects in the experiments. They carefully observed signs of myocarditis, inflammation of the heart muscle and problems in children, as there were several cases among older children and adults. Myocarditis was not detected in young children.

Effectiveness of the vaccine

Both vaccines were tested when the Omicron variant was the predominant strain of the coronavirus. Studies have shown that this particular option, regardless of age or dose, has been successful in avoiding the protection offered by the two companies ’vaccines.

The Omicron option was generally challenging for this age group. According to a CDC report in March, hospitalizations for children 5 and younger due to a lack of vaccines were five times higher in the winter than at the peak of Omicron, compared to the strain that dominated the Delta variant last summer.

Modern is estimated to be 36.8% effective against symptomatic disease in children aged 2 to 5 years and 50.6% protective against symptomatic disease in children aged 6 to 23 months.

Pfizer was vaccinated in a trial for the vaccine, and there were only 10 Covid cases in the placebo group – a very small number to evaluate the effectiveness of the vaccine. According to the company, the effective data from the preliminary results are “encouraging”. The FDA said the immune response to the vaccine between the ages of 6 and 23 months and between the ages of 2 and 4 years is comparable to the immune response of older participants, but more research is needed.

Corollary: Get vaccinated

Get the vaccine available, experts say.

“I don’t think it’s clear that one is better than the other. They’re different,” Polsen said. “It’s a favorite thing of parents. It’s about balancing the differences, and, frankly, what’s up and what’s going on at their pediatrician or what’s going on at the local hospital.”

Doctors also recommend searching the Internet or calling to find out what the local site offers. Not every place offers both axes. Some vaccine clinics may not offer vaccines to young children or may have age restrictions. For example, CVS stores that have MinuteClinics vaccinate this new age group, but only if the child is 18 months or older.

Vaccines.gov may be helpful. The website provides some information on clinics listed by category.

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