The dominant coronavirus mutant in the country is a reflection of a past pandemic

The mutated coronavirus, which currently dominates the United States, belongs to the omicron family, but scientists say it spreads faster than previous omicrons, is immune-capable, and can cause more serious illness. What for? Because it combines the properties of both omicron and delta, the predominant variant of the nation in the middle of last year. A genetic feature that goes back to the past of the so-called “delta mutation” pandemic allows the virus to “avoid the immunity it had before vaccination and previous infection, especially if you were infected with an omicron wave,” the doctor said. . Wesley Long, a Houston Methodist pathologist in Texas. This is because the original omicron strain that covered the world did not have mutations. Omicron’s “sub-variant” is gaining momentum in the U.S. – known as BA.2.12.1 and was responsible for 58% of COVID-19 cases in the U.S. last week – and is not the only person to have suffered from a Delta mutation. Genetic modification is also present in the omicron relatives that predominate in South Africa, known as BA.4 and BA.5. They have the same mutation as the delta, and have an almost identical mutation in BA.2.12.1. This genetic modification is bad news for those who hold the original omicron and think they will not be re-infected with COVID-19 any time soon. While most people don’t know exactly which option led to their illness, the original omicron created a wave of major cases late last year and early this year. Long-standing laboratory data suggest that the original infection with the original omicron was less protected against re-infection with new mutants, but the real risk of re-infection, regardless of the variant, is unique to each person and situation. There may be additional weapons earlier by Delta. to protect new mutants. The study, published by researchers at Ohio State University before being reviewed by other scientists, found that COVID patients undergoing intensive care with delta-borne infections were better at neutralizing new mutants than patients with primary omicrons. Shan-Lu Liu is the author of a study co-led by a program of viruses and emerging pathogens in Ohio. But Liu said the level of protection against delta infection is partly due to how long someone has been ill. Because over time, immunity declines. People with delta should not think they are immune to new subvalants, especially if they have not been vaccinated, Long said. “I can’t say no one is safe.” A bright spot? The booster bullet can provide strong protection against new mutants, Liu said. In general, vaccines and previous infections can protect people from the worst effects of COVID-19. Scientists say it is too early to know if the new mutant will gain momentum in the United States and lead to a new increase in new cases, hospitalizations and deaths. Scientists are still trying to determine how virulent these new mutants are. Long said he had not seen anything to answer that question, but Liu said the new data showed a more serious illness. Liu said that subvariants have properties that can be effectively transmitted from cell to cell. The virus “simply hides in the cell and spreads from cell to cell through contact,” Liu said. “It’s dangerous because the virus doesn’t come out to make antibodies work.” Dr. According to Eric Topol, director of the Scripps Institution of Translation Studies, the new mutants certainly do not appear to be less virulent than previous versions of omicron, and it will “become clear in the coming months” whether they are more virulent or not. so that they spread faster than before. Although home testing makes it difficult to track all U.S. COVID cases, Johns Hopkins University data show an average of 107,000 cases per day, up from 87,000 two weeks ago. According to the Centers for Disease Control and Prevention, admission of patients with COVID-19 to the new hospital has been on an upward trend since about April. “I hope we don’t see such an increase in hospitalizations. It was in the previous waves,” Long said. “But with COVID, the more people you have, the more it’s a numbers game. Some of those people get tough. Some of them need to be hospitalized. Some of them, unfortunately, pass away.”

The mutated coronavirus, which currently dominates the United States, belongs to the omicron family, but scientists say it spreads faster than previous omicrons, is immune-capable, and can cause more serious illness.

Why? Because it combines the properties of both omicron and delta, the most popular variant of the nation in the middle of last year.

A genetic feature that goes back to the past of the so-called “delta mutation” pandemic allows the virus to “avoid the immunity it had before vaccination and previous infection, especially if you were infected with an omicron wave,” the doctor said. . Wesley Long, a Houston Methodist pathologist in Texas. This is because the original omicron strain that covered the world did not have mutations.

Known in the U.S. as BA.2.12.1 and responsible for 58% of U.S. COVID-19 cases last week, the omicron “subvariant” is not the only person to have suffered a delta mutation. Genetic modification is also present in the omicron relatives that predominate in South Africa, known as BA.4 and BA.5. These have a delta-like mutation, while BA.2.12.1 has an almost similar mutation.

This genetic change is bad news for people who have captured the original omicron and think they will not be able to re-infect COVID-19 any time soon. While most people don’t know exactly which option led to their illness, the original omicron created a wave of major cases late last year and early this year.

Long-standing laboratory evidence suggests that the original infection with the original omicron did not provide much protection against re-infection with new mutants, but in either case, the risk of re-infection is unique to each individual and situation.

However, people with delta disease may already have additional weapons to avoid new mutants. The study, published before being reviewed by other researchers by Ohio State University researchers, showed that COVID patients undergoing intensive care with delta-borne infections were better at neutralizing new mutants than patients with primary omicron.

“Antibodies to omicron infection are not well protected against subvalants compared to delta,” he said. Shan-Lu Liu is the author of a study co-led by a program of viruses and emerging pathogens in Ohio.

However, according to Ludin, the level of protection against delta infection depends on how long someone has been ill. This is because over time, immunity declines.

People with delta should not feel unaffected by new subvalances, especially if they have not been vaccinated, Long said. “I can’t say no one is safe.”

A bright place? The booster bullet can provide strong protection against new mutants, Liu said. In general, vaccines and previous infections can protect people from the worst effects of COVID-19. At the same time, scientists say it is too early to know whether the new mutant will lead to a significant increase in new cases, hospitalizations and deaths in the United States.

Scientists are still trying to determine how dangerous these new mutants are. Long said he had not seen anything to answer that question, but Liu said the new data showed a more serious illness. Liu said that subvariants have properties that can be effectively transmitted from cell to cell.

The virus “simply hides in the cell and spreads from cell to cell through contact,” Liu said. “It’s dangerous because the virus doesn’t come out to make antibodies work.”

Dr. According to Eric Topol, director of the Scripps Institution of Research Translation, the new mutants certainly do not appear to be less virulent than previous versions of omicron, and whether they are virulent will be “clear in the coming months.”

At the same time, scientists expect the latest mutants to spread faster because they are more contagious than their predecessors.

Although home testing makes it difficult to track all U.S. COVID cases, Johns Hopkins University data show an average of 107,000 cases per day, up from 87,000 two weeks ago. According to the Centers for Disease Control and Prevention, admission of patients with COVID-19 to the new hospital has been increasing since mid-April.

“I hope we don’t see an increase in hospitalizations in the previous waves,” Long said. “But with COVID, the more people you have, the more it’s a numbers game. Some of those people get tough. Some of them need to be hospitalized. Some of them, unfortunately, pass away.”

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