Surprising cases of hepatitis in children have reached 109 in 25 states, the CDC said

The Centers for Disease Control and Prevention has been investigating 109 unexplained hepatitis cases in children from 25 states over the past seven months. Of the 109 injured, five died and 15 (14 percent) needed a liver transplant. All children were under the age of 10, and 90 percent were hospitalized.

The CDC’s announcement on Friday represents a sharp rise in the number of cases in the United States, limited to nine cases confirmed three weeks ago in Alabama. The work also includes a global figure of more than 300 cases from more than 20 countries.

However, despite the increase in cases, CDC and international health investigators are still puzzled about the cause of the disease. Severe hepatitis is rare in young children, and unexplained cases of severe hepatitis are rare.

So far no general effects, travel, medications, food or drink cases have been combined. The CDC and other health agencies have ruled out viruses that cause hepatitis in children, such as hepatitis A to E.

They also ruled out vaccination with COVID-19 as a possible cause, as most children have not been vaccinated – most of them are currently unfit for vaccination due to their age. “The COVID-19 vaccine is not the cause of these diseases and we hope this information will help clarify some of the predictions that have been circulating on the internet,” Jay Butler, the CDC’s deputy director of infectious diseases, said at a briefing on Friday.

The CDC has already denied that SARS-CoV-2 is the cause, noting that all of the first known cases in Alabama have been tested negative for the pandemic virus. These nine cases were also in the history of SARS-CoV-2 infection. However, Butler said at a news briefing on Friday that this could play a role if the agency is considering testing antibodies in children affected by the virus to determine if some have previously been infected with SARS-CoV-2.

The UK Public Health Agency (UKHSA) and others suggest that cases of hepatitis may be related to a previous infection with SARS-CoV-2 and may be an additional factor in later hepatitis.

adenovirus link

However, the basic hypothesis remains that adenovirus contributes in some cases. Butler said more than half of the 109 cases reported by the CDC were positive for adenovirus. All five Alabama subtypes tested positive for 41 strains of adenovirus.

At a UKHSA technical briefing on Friday, the agency said the number of cases in the UK had risen to 163. Of the 126 cases tested for adenovirus, 91 (72 percent) passed a positive test. Of the 18 successful subtypes, 18 were positive for 41 types of adenovirus.

Adenoviruses are a large family of common viruses, most commonly associated with mild respiratory illness in children and pink eyes. Adenovirus type 41, however, is a type that is commonly referred to as gastrointestinal disease. Adenoviruses are sometimes associated with cases of hepatitis, but these cases are almost always found in immunocompromised children. Most cases of unexplained hepatitis occur in previously healthy children.

At a UKHSA technical briefing on Friday, the agency listed updated working hypotheses.

The increase in non-AE forms of acute hepatitis in children is due to the following reasons:

  1. A common adenovirus infection is related to one of them [the possibilities below]:
    The. Abnormal susceptibility or host response to adenovirus infection due to non-exposure to hepatitis (whether direct or immunopathological), such as a coronavirus (COVID-19) pandemic.
    В. A particularly large wave of conventional adenovirus infections leads to the frequent occurrence of very rare or lesser-known complications.
    ç. Abnormal susceptibility or host response to adenovirus due to pre-infection with SARS-CoV-2 (including Omicron limited) or other infections.
    г. Abnormal susceptibility or host response to adenovirus due to co-infection with SARS-CoV-2 or other infections.
    and the. Abnormal susceptibility or host reaction to adenovirus due to exposure to a toxin, drug, or environment.
  2. A new variant of adenovirus, with or without the addition of cofactors as listed above.
  3. Post-infectious SARS-CoV-2 syndrome (including Omicron limited effect).
  4. Drugs, toxins or environmental effects.
  5. The new pathogen acts alone or as a co-infection.
  6. A new version of SARS-CoV-2. “

Leave a Comment

Your email address will not be published.