Studies show that Pfizer’s antiviral has little or no benefit in young adults, and the WHO says the BA.5 omicron subvariant accounted for 74% of cases in the last week.

Pfizer’s COVID antiviral Paxlovid seems to have little or no benefit in youthful individuals, however it nonetheless reduces the threat of hospitalization or demise in older adults, in line with a brand new Israeli examine.

The Associated Press reported that knowledge from a examine of 109,000 sufferers may renew questions on the US authorities’s use of Paxlovid, which has grow to be a mainstay therapy for COVID-19 as a result of of its comfort at dwelling.

The Biden administration has spent greater than $10 billion to purchase the drug and make it out there at hundreds of pharmacies by means of the Test and Treat Initiative. Biden himself took Paxlovid in his last bout with COVID.

The researchers discovered that Paxlovid lowered hospital admissions by about 75% in individuals 65 and older shortly after an infection. This is per earlier findings used to weigh drug approvals in the US and elsewhere.

But individuals between the ages of 40 and 65 noticed no measurable benefit, in line with an evaluation of medical data.

The examine has limitations associated to its design, which included knowledge from a big Israeli well being care system as an alternative of enrolling sufferers in a randomized managed trial—the gold normal for medical analysis.

“Paxlovid stays vital for individuals at excessive threat of COVID-19, reminiscent of the aged and these with compromised immune techniques,” mentioned Dr. University of Minnesota researcher and doctor David Bulwer, who was not concerned in the examine, advised the AP. “But for the overwhelming majority of eligible Americans proper now, it does not actually do a lot good.”

Pfizer PFE consultant,
The New England Journal of Medicine declined to touch upon the findings.

The information comes as recognized cases of COVID in the U.S. start to ease, however given how many individuals are being examined at dwelling and knowledge not being collected, the true quantity could also be larger than reported.

Read now: Dr. Fauci’s recommendation was at all times easy and acquainted

The each day common of new cases on Wednesday was 91,383, a 16% drop from two weeks in the past, in line with a New York Times tracker. The each day common of hospitalizations fell 8% to 39,443, whereas the each day common of deaths fell 4% to 458.

According to the World Health Organization, cases worldwide fell by 9% in the week to August. Compared to last week, 21, the quantity of deaths decreased by 15%.

The company’s weekly epidemiological replace discovered that the BA.5 omicron variant predominated globally, accounting for 74% of cases listed in the world database, up from 71% every week earlier.

Overall, omicron variants accounted for 99% of the sequences reported worldwide in the last 30 days.

News about the coronavirus: MarketWatch’s each day roundup has up to date and reported on all the newest developments each enterprise day since the begin of the coronavirus pandemic

Other COVID-19 information it’s good to know:

• Trump White House officers tried to strain US well being consultants to reauthorize a discredited COVID-19 therapy, in line with a congressional investigation, offering new proof of the administration’s try and overturn Food and Drug Administration choices early in the pandemic, in line with a congressional investigation. AP. A report by the House subcommittee on the coronavirus disaster on Wednesday additionally sheds new gentle on the position of tv personalities in bringing hydroxychloroquine to the consideration of White House officers. Investigators highlighted emails from Fox News’ Laura Ingraham and others to Mehmet Oz, a famend coronary heart surgeon who hosts a daytime TV show and is now a Republican Senate candidate in Pennsylvania. Ingram attended an Oval Office assembly with President Donald Trump when he mentioned he took malaria treatment.

From the archives (February 2022): Ivermectin and hydroxychloroquine extra more likely to be prescribed in Republican counties, examine finds

See additionally (December 2020): A House panel mentioned the Trump administration has tried to dam or alter dozens-plus coronavirus reviews

• Since well being officers confirmed the first cases of COVID-19, misinformation has unfold as rapidly as the coronavirus. Social media could have made the quantity, selection and pace of misinformation unprecedented, however COVID-19 is just not the first pandemic in which false and dangerous info has hampered public well being, writes Christian Apetrey, professor of immunology, infectious ailments and microbiology. University of Pittsburgh Health Sciences. Misinformation modified individuals’s belief in governments and medical doctors throughout the 1918 flu pandemic. He impressed the smallpox vaccine actions of the nineteenth century by means of some of the identical arguments used at present in opposition to the COVID-19 vaccine.

• North Korea mentioned Thursday it had discovered 4 new cases of fever attributable to coronavirus infections in its border area with China, two weeks after chief Kim Jong-un declared a extensively disputed victory over COVID-19. North Korea’s state-run Korean Central News Agency mentioned medical officers have been finishing up genetic evaluation of samples taken from 4 individuals with fever in Ryanggang province to verify whether or not they have been attributable to a “malicious outbreak”. North Korea typically makes use of the time period, together with “dangerous virus,” to explain COVID-19 and the coronavirus.

According to North Korean state media, Kim Jong-un’s sister instructed that the dictator himself was contaminated with Covid-19. The bulletins got here three months after the nation declared victory over the virus, reporting a spike in cases. Photo: KCNA/Reuters

• A Texas man was sentenced to 6 months in federal jail Tuesday for threatening a Maryland physician who was a distinguished advocate of a COVID-19 vaccine, the AP reported, citing federal prosecutors. Scott Eli Harris, 52, of Aubrey, Texas, pleaded responsible in February to creating threats by interstate communication. US Attorney of Maryland Eric L. Barron introduced the three-year sentence in a press launch Wednesday.

Here’s what the numbers say

The world quantity of confirmed cases of COVID-19 exceeded 599 million on Tuesday, whereas the demise toll exceeded 6.48 million, in line with Johns Hopkins University.

The US leads the world with 93.9 million cases and 1,042,709 deaths.

A tracker from the Centers for Disease Control and Prevention exhibits that 223.7 million individuals dwelling in the US are absolutely vaccinated, which is 67.4% of the whole inhabitants. However, solely 108.2 million persons are 48.4% of the vaccinated inhabitants.

Only 21.4 million individuals age 50 and older had a second sponsor, in comparison with 33.2% of those that obtained a primary booster.


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