Media Council

Monday, June 13, 2022

Forty percent of all older people and 50 percent of Alzheimer’s patients may have a nightmare.


A study funded by the New National Institutes of Health found that brain changes from TDP-43 encephalopathy (LCD) in limbic predominant age can occur in about 40% of older people and up to 50% in people with Alzheimer’s disease. This reliable assessment is based on 13 community and population-based surveys from five countries and was published in the journal today. Acta Neuropathologica. NIGHT is a recently recognized brain disorder that mimics the clinical signs of Alzheimer’s, the most common form of dementia. LATE people sometimes have one or more brain diseases, such as Alzheimer’s disease, and in such cases, they may have worse symptoms.

This new study included autopsy, genetic, and clinical data from 6,196 study participants and adds growing evidence that various disorders and disease processes contribute to dementia. Significant contributions from samples and data came from 10 Alzheimer’s disease research centers (ADRCs) and related studies funded by the NIH National Institute on Aging (NIA). Through ADRCs, people are given the brain to examine the corpse after death. ADRC scientists provide the results of the examination to families and contribute to a national database that provides the wider research community with information on risk factors, symptoms, and other factors for neurodegenerative diseases. The brain donor is an important part of the discovery and makes such discoveries possible. More research is needed on a wider group of people to fully understand the risk factors and LATE symptoms.

World Health Organization

NIA experts will review the specific findings of this document and / or the state of the study of Alzheimer’s disease and related dementia, as well as interviews to discuss the importance of FORGIVENESS and participation in brain donation and clinical trials.

  • Eliezer OliveMD, Director, NIA Department of Neuroscience
  • Nina SilverbergPh.D., Director, Alzheimer’s Disease Centers Program, NIA Department of Neuroscience

The research was funded in part by NIA grants P30AG072958, P30AG072977, K08AG065463, RF1AG072080, K08AG065426, R01AG038651, UF1AG057707, R01AG021055, P30AG066519, R01AG061111, R01AG057187, P30AG072946, R01AG054449, RF1AG069052, P30AG072972, R01AG062517, U19AG069701, K24AG053435, R01AG067482, R01AG064233, R01AG022018 , P30AG010161, P30AG072975, P30AG062677, U01AG006786, R01AG034676, P30AG66509 and U19AG066567.

The NIA oversees the NIH’s systematic planning, development, and research phases to achieve the goal of effective treatment and prevention of Alzheimer’s and related dementia. These activities report to the NIA’s AD + ADRD phases:

  • 2.P, “Determination of the mechanism of pathogenesis and toxicity of TDP-43 and FUS.”
  • 2.U, “Identification of the main pathobiological and molecular mechanisms of cellular TDP-43, post-translational modifications such as phosphorylation and pathology in symptomatic and manifest dementia.

A link

Nelson P, et al. Frequency of Late Neuropathological Changes in the Spectrum of Neuropathology of Alzheimer’s Disease: Data from 13 community or population-based autopsy cohorts. Minute Neuropathy. doi: 10.1007 / s00401-022-02444-1.

About the National Institute on Aging (NIA): The NIA directs the efforts of the U.S. federal government to conduct and support research on the health and well-being of the elderly. Learn more about age-related cognitive changes and neurodegenerative diseases through the NIA’s Alzheimer’s and Related Dementias Education and Referral (ADEAR) website. For information on a range of aging topics in English and Spanish, visit the main NIA website and stay in touch.

About the National Institutes of Health (NIH):The NIH, the country’s medical research agency, includes 27 institutes and centers and is part of the U.S. Department of Health and Human Services. The NIH is a major federal agency that conducts and supports basic, clinical, and translational medical research and investigates the causes, treatments, and treatments for common and rare diseases. For more information about NIH and its programs, visit

NIH… Turning openness into health®