New research shows that vitamin D deficiency leads to dementia

New genetic research finds a direct link between dementia and vitamin D deficiency.

Dementia – a decrease in cognitive function with the loss of the ability to remember, think, solve problems or make decisions – if it has reached a level that interferes with daily activities. This is a broad term, not a specific disease.[{” attribute=””>Alzheimer’s disease is a specific type of dementia and the most common, with 6 million Americans afflicted according to the Alzheimer’s Association.

It is not a normal sign of aging, even though it primarily affects older adults at least 65 years of age. According to the CDC, nearly 14 million Americans will be suffering from dementia by 2060.

Dementia is one of the major causes of disability and dependency among older people worldwide, affecting thinking and behaviors as you age. But what if you could stop this degenerative disease in its tracks?

A world-first study from the University of South Australia could make this a reality as new genetic research shows a direct link between dementia and a lack of vitamin D.

Investigating the association between vitamin D, neuroimaging features, and the risk of dementia and stroke, the study found:

  • low levels of vitamin D were associated with lower brain volumes and an increased risk of dementia and stroke.
  • genetic analyses supported a causal effect of vitamin D deficiency and dementia.
  • in some populations, as much as 17 percent of dementia cases might be prevented by increasing everyone to normal levels of vitamin D (50 nmol/L).

Dementia is a chronic or progressive syndrome that leads to deterioration in cognitive function. About 487,500 Australians live with dementia and it is the country’s second leading cause of death. Globally, more than 55 million people have dementia with 10 million new cases diagnosed every year.

Supported by the National Health and Medical Research Council, the genetic study analyzed data from 294,514 participants from the UK Biobank, examining the impact of low levels of vitamin D (25 nmol/L) and the risk of dementia and stroke. Nonlinear Mendelian randomization (MR) – a method of using measured variation in genes to examine the causal effect of a modifiable exposure on disease — were used to test for underlying causality for neuroimaging outcomes, dementia, and stroke.

Mendelian randomization is a epidemiological method of using measured variation in genes of known function to analyze the causal effect of a modifiable disease exposure on an outcome in observational studies.

Senior investigator and Director of UniSA’s Australian Centre for Precision Health, Professor Elina Hyppönen, says the findings are important for the prevention of dementia and appreciating the need to abolish vitamin D deficiency.

“Vitamin D is a hormone precursor that is increasingly recognized for widespread effects, including on brain health, but until now it has been very difficult to examine what would happen if we were able to prevent vitamin D deficiency,” Prof Hyppönen says.

“Our study is the first to examine the effect of very low levels of vitamin D on the risks of dementia and stroke, using robust genetic analyses among a large population.

“In some contexts, where vitamin D deficiency is relatively common, our findings have important implications for dementia risks. Indeed, in this UK population we observed that up to 17 percent of dementia cases might have been avoided by boosting vitamin D levels to be within a normal range.”

The findings are incredibly significant given the high prevalence of dementia around the world.

“Dementia is a progressive and debilitating disease that can devastate individuals and families alike,” Prof Hyppönen says.

“If we’re able to change this reality through ensuring that none of us is severely vitamin D deficient, it would also have further benefits and we could change the health and wellbeing for thousands.”

“Most of us are likely to be ok, but for anyone who for whatever reason may not receive enough vitamin D from the sun, modifications to diet may not be enough, and supplementation may well be needed.”

Reference: “Vitamin D and brain health: an observational and Mendelian randomization study” by Shreeya S Navale, Anwar Mulugeta, Ang Zhou, David J Llewellyn and Elina Hyppönen, 22 April 2022, The American Journal of Clinical Nutrition.
DOI: 10.1093/ajcn/nqac107

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