Neuroimaging studies reveal age and gender-related differences in fatigue

Summary: Age and gender influence the relationship between state fatigue and brain activation.

A source: Kessler Foundation

To study the relationship between age and fatigue, Kessler Foundation researchers conducted a novel study using neuroimaging self-report data.

Their results were published on the Internet on May 9, 2022 Frontiers in Human Neuroscience.

Authors: Glenn Wiley, DPhil, Amanda Pra Sisto, Helen M. Genova, Ph.D. and John DeLuca, Ph.D., Kessler Foundation. All Rutgers New Jersey medical schools have faculty appointments. Dr. Wiley is also an investigator at the Department of Veterans Affairs’ Center for War-Related Injuries and Disease Research at the New Jersey Health Care System.

Their study is the first to investigate the effects of gender and age on “state” and “trait” fatigue, and is the first to report fatigue-related differences in brain activation across the lifespan and across gender during a cognitive fatigue task.

The “state” fatigue measure assesses the subject’s instantaneous fatigue experience during testing; The “trait” measure of fatigue assesses how tired the subject is over an extended period of time, such as the previous four weeks.

The researchers collected data on fatigue and state fatigue from 43 healthy men and women between the ages of 20 and 63. State fatigue was measured during fMRI scans while participants performed a cognitively challenging task.

Their study is the first to investigate the effects of gender and age on “state” and “trait” fatigue, and is the first to report fatigue-related differences in brain activation across the lifespan and across gender during a cognitive fatigue task. Image is in the public domain

The study was conducted at the Rocco Ortenzio Neuroimaging Center at the Kessler Foundation, a facility dedicated exclusively to rehabilitation research. They reported that older people were less likely to experience fatigue.

Dr. “Our neuroimaging data show that the role of the mesofrontal regions of the brain changes with age,” said Wiley, director of the Ortenzio Center. Younger people may use these places to fight fatigue, but older people don’t. In addition, these results indicate greater resilience when women are exposed to stressful work.

“This study is an important first step in the literature that explains some of the differences in fatigue, that the state and characteristics of fatigue measure different aspects of fatigue, and that age and gender influence the relationship between the state of fatigue and brain activation. ,” Dr. Weil concluded.

This fatigue research is about news

Author: Press service
A source: Kessler Foundation
The connection: Press service – Kessler Foundation
Photo: Image is in the public domain

Original research: Open access.
“Lifetime Fatigue in Men and Women: State vs. Trait” by Glenn R. Wiley et al. Frontiers in Human Neuroscience

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Abstract

Lifetime Fatigue in Men and Women: State vs. feature

Purpose: It is generally thought that fatigue worsens with age, but the literature is mixed: some studies show that older people develop more fatigue, while others show the opposite. Some of the inconsistencies in the literature may be due to gender differences in fatigue, while others may be due to differences in the instruments used to study fatigue because of the correlation between state (current) and trait (over time). Fatigue is proven to be weak. The aim of the current study was to examine mood and fatigue across age and gender using neuroimaging and self-report data.

Methods: We examined the effects of age and gender on fatigue in 43 healthy individuals, using the Modified Fatigue Impact Scale (MFIS), a self-reported trait measure. We also performed fMRI scans on these individuals and collected measures of state fatigue using the visual analog scale of fatigue (VAS-F) during the fatigue task.

Results: There was no correlation between age and total MFIS score (fatigue) (r = –0.029, P = 0.873), and there was no gender effect [F(1,31) < 1]. However, for state fatigue, increasing age was associated with less fatigue [F(1,35) = 9.19, p < 0.01, coefficient = –0.4]. In neuroimaging data, it interacts with VAS-F in the medial frontal gyrus. In younger adults (20-32), greater activity was associated with less fatigue, no relationship for those aged 33-48, and in older adults (55+), greater activity was associated with greater fatigue. Genes also interacted with VAS-F in multiple regions, including the orbital, middle, and inferior frontal gyrus. For women, greater activity was associated with less fatigue, and for men, greater activity was associated with greater fatigue.

A result: Older adults reported less fatigue during the task (state measures). Neuroimaging data show that the role of medial frontal regions varies with age: young people may use these regions to cope with fatigue, but older people do not. Furthermore, these results may suggest that women are more flexible than men when faced with a fatigue task.

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