“Our outcomes help that statin remedy doesn’t cause muscle ache in folks taking statin remedy,” stated the study, led by the authors of the Oxford Population Health and Medical Research Council’s Population Health Research Unit, University of Oxford. “This discovering is especially true if therapy is properly tolerated for a yr or extra earlier than signs develop.”
The authors carried out a meta-analysis of 19 randomized, double-blind trials of statin regimens versus placebo. All trials concerned greater than 1,000 members and continued for a minimum of two years. They additionally reviewed 4 double-blind trials of more- and less-intensive statin regimens.
According to study creator Colin Baigent, a professor of epidemiology on the University of Oxford, there have been many non-randomized research that didn’t embody any placebo or random project to statins. How a lot muscle ache do statins cause?
“It’s made patients stop beginning statins or stop therapy once they get muscle ache because they only have a look at the paper and see that statins cause an increasing number of muscle ache and stop,” Baigent stated throughout Science Media. Center briefing. “We actually tried to cope with this drawback.”
The new study says that “even within the first yr of a moderate-intensity statin routine, just one in 15 patients reporting muscle signs might have a cause, and the quantity will increase to about one in 10 in these taking them.” intensive mode.
“In different phrases, the statin is just not the cause of muscle signs in additional than 90% of individuals who report such signs.”
The authors discovered a 7% relative improve in muscle ache or weak point in the course of the first yr of statin remedy, but no important improve thereafter. The elevated danger was solely inside the first three months after therapy was prescribed.
During a median follow-up of 4.3 years, a minimum of one episode of muscle ache or weak point was reported in 27.1% of statin patients versus 26.6% of placebo patients.
In the trials reviewed by the authors, they report an estimated 11 extra muscle pains per 1,000 patients within the first yr of statin remedy.
“We’ve come to the conclusion that as a occupation, as a society, we have to do two issues,” Baigent stated on the briefing. “First, we have to do a higher job of managing patients who report muscle ache whereas taking a statin, because patients have a tendency to stop taking a statin, and that may have a unfavorable influence on their long-term well being. We must evaluate the knowledge.
He famous that if folks had been higher knowledgeable about the actual dangers of muscle ache, they could keep on statin remedy longer.
The study has some limitations, together with appreciable heterogeneity within the strategies used for muscle signs, some opposed occasion knowledge not being obtainable, and exclusion of most members, now categorized as statin intolerance research.
In a commentary printed alongside the study, Dr. Maciej Banach, a heart specialist on the Medical University of Lodz and a heart specialist on the Polish Mother Memorial Hospital Research Institute in Poland, wrote that the potential uncomfortable side effects of statins shouldn’t be taken into consideration when beginning therapy.
“It ought to be robust. Muscle signs emphasize that the small danger is insignificant in comparison with the excessive confirmed cardiovascular advantages of statins,” he wrote.
Last week, the US Preventive Services Task Force launched its newest pointers for statin use to forestall a first coronary heart assault or stroke.
The pointers are extra conservative than these issued by different teams, such because the American College of Cardiology. They advocate statins to adults ages 40 to 75 who’ve one cardiovascular danger issue and a 10% or larger danger of coronary heart assault within the subsequent 10 years.