Information on intestinal contusions

Summary: According to a new study, signs of concussion can be found in the gut. Scientists have found a link between the brain’s injured proteins in the blood samples and a bacterium associated with the brain injury.

A source: Houston Methodist

A recent study by Methodist scientists in Houston suggests that signs of concussion may be found in the gut. Using blood, feces and saliva samples from 33 Rice University footballers, the researchers were able to study the diagnostic potential of intestinal microbiome.

According to them, their results show that a simple, objective diagnostic test can be developed to monitor the effects of concussions and to determine when it is safe to return to action.

The results of this study are presented in the May issue of the article “Changes in the intestinal microbiome after sports-related concussions in the collegiate football cohort: a pilot study.” Brain, Behavior and Immunity – Health, A reviewed journal of the Psychoneuroimmunology Research Society, focuses on studies that have translation effects and clinical implications. Sonia Villalapol, Ph.D., assistant of neurosurgery at the Center for Neuroregeneration at the Houston Methodist Research Institute, author of the study.

Although the movement of the brain inside the skull can damage nerve cells, such microscopic cell injuries are not seen on visual tests such as X-rays, CT and MRI, which can detect fractures of the skull, bleeding from the brain or injuries on a scale. tumor.

Thus, the most commonly used test for the diagnosis of concussion relies solely on self-reported symptoms such as blurred vision, dizziness, vertigo, and headache, which are very vague, subjective, and often not reported by athletes who want to continue playing. This makes it difficult to diagnose them.

A one-season study found that two common bacterial strains in the feces of healthy people dropped a drop after a concussion. He also found a correlation between proteins associated with traumatic brain injury in the blood and bacterial species associated with a brain injury in the feces.

Although dozens of biomarkers of brain injury have been identified, progress has been made in developing commercial blood tests that are sensitive enough to detect a slight increase in biomarker concentrations.

However, the central nervous system is closely linked to the gastrointestinal nervous system, occurs in the gut, and head trauma constantly leads to changes in the gut microbiota, Villiapol said.

After a concussion, injuries cause inflammation, sending small proteins and molecules into the bloodstream, breaking down the intestinal barrier, causing changes in the gut, and affecting metabolism.

According to him, these changes in the microbiota will provide information about the ongoing damage to the central nervous system.

“Until your gut microbiome returned to normal, you didn’t recover,” Villapol said. “So it is very helpful to study the intestines. This is not a lie. Therefore, there is great interest in using it for diagnostic purposes. ”

He also found a correlation between proteins associated with traumatic brain injury in the blood and bacterial species associated with a brain injury in the feces. Image in public domain

Although only four players were diagnosed with concussions, the researchers said the results needed to be confirmed on a larger scale. They also plan to conduct a similar study in the near future using female footballers who have suffered frequent head injuries.

“Women and men don’t have the same immunity or gut microbiome, and I, as a mother of women and girls, hate to be a researcher who ignores women and focuses only on men’s issues,” Villyapol said.

“The level of concussions in female footballers is very high and they have the same problems when it comes to current diagnostic methods.”

Villapol’s collaborators in the study were researchers from Rice University, Kristen Curry, Qi Wang, Michael Nutt, Elizabeth Reeves, Sarah Shodroff and Todd Treangen from the Departments of Computer Science and Athletics; and Houston Methodist colleagues Sirena Soriano, Said S. Sadrameli, Rasadul Kabir, Jonathan Viz, Amber Chriswell, Gavin W. Brittz, Rajan Gadhia and Kenneth Podell.

Funding: This work was supported by the National Institute of Neurological Diseases and Stroke (grant number R21NS106640), the Hamill Innovation Award of the Institute of Biology and Bioengineering, the National Institute of Allergy and Infectious Diseases (grant number P01AI152999-01) and the Methodist of the Houston Research Institute. .

It’s about concussion and microbiome research news

Author: Lisa Merkle
A source: Houston Methodist
The connection: Lisa Merkel is a Houston Methodist
Photo: Image in public domain

Original study: Open access.
Sirena Soriano Brain, Behavior and Immunity – Health


Abstract

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Changes in the intestinal microbiome after a sports-related concussion in a collegiate football team: a pilot study

Contusions, alone and repetitive, can lead to changes in athletes’ brains and bodies during contact sports. The role of brain-intestinal communication and changes in the microbiota have not been well established after sports-related concussions or recurrent subconjunctival effects.

We hired 33 players from Division I Collegiate and collected blood, feces and saliva samples at three times during the sports season: in the middle of the season, after the last competitive game (post-season) and after the holiday season. season.

Additional samples were taken from four athletes with concussions. 16 rRNA sequences of the intestinal microbiome revealed a decrease in abundance for two species of bacteria, Eubacterium rectale and Anaerostipes hadrus, after a diagnosed concussion.

No significant differences were found in the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during competition. In addition, blood levels of S100β and SAA were positively correlated with the prevalence of Eubacterium rectale species in the group of non-concussed athletes diagnosed during the sports season.

These findings provide initial evidence that the detection of changes in the intestinal microbiome could help improve the diagnosis of post-traumatic concussion.

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