Paxlovid, an antiviral drug designed to prevent hospitalization and death from COVID-19, is usually prescribed to patients with SARS-CoV-2 infection.
The highly effective drug has a list of 7 common potential side effects, including one that altered the sense of taste that social media users call “Paxlovid Mouth”.
Although the side effects are temporary, health experts say that there are several preconditions and medical histories that this antiviral drug can harm your health.
Below you will learn: What is Paxlovid and how does it treat COVID-19?; The A complete list of possible side effects associated with paxlovid; What is “Paxlovid Mouth” and why can a bitter, bitter taste occur; and the if it is safe to take Paxlovid.
Paxlovid is an antiviral drug that can help those who are at high risk of death or severe complications of COVID-19 to recover without going to the hospital. Some doctors may call the product “life-saving” and for good reason – according to the latest data from the Food and Drug Administration (FDA), 90% of COVID-19 hospitalizations are among people who have not been vaccinated with Paxlovid, are over 65 years old and have weakened immune systems. can prevent. people. While many health professionals prescribe antiviral treatment consisting of two individual medications, nimatrelvir and the ritonavir – Americans who recovered quickly during the Omicron epidemic are noticing that the pill is not without its drawbacks.
There has been a lot of talk on social media platforms about the potential negative effects of Paxlovid on some people, in particular what is now known as the Paxlovid Mouth.
“Oh, my doctor didn’t joke about the rough taste in your mouth when you took Paxlovid,” said one user recently. On Twitter. “Paxlovid tablets are tasteless, but they always give my mouth a metallic and bile taste. It’s really pleasant.” another watched. Someone else noted“It’s been a few hours since I took the first dose of Paxlovid, but he’s doing something. I have a strong metallic taste of grapefruit in my mouth, but my chest is constricted and I can breathe deeply. I fell to 64 at the age of 86 after walking.”
The drug manufacturer, Pfizer, is currently distributing its effective COVID-19 treatment under the permission of FDA officials for emergency use; Researchers are still learning more about Paxlovid this year, including a relapse of possible symptoms for some people. But medical staff have already been notified about seven other possible side effects It comes with antiviral pills and patients are currently learning more about them.
Continue reading to learn about the possible side effects of Paxlovid, including the altered taste sensation known as “Paxlovid Mouth”.
What is Paxlovid and how does it treat COVID-19 symptoms?
Antiviral drugs for people over 12 years of age – COVID-19 is a good opportunity to hear from your primary care provider about Paxlovid to reduce your risk of developing the disease. Treatment is a combination of two individual medications (packaged in two different colored tablets!) And is usually prescribed for five days after the diagnosis of COVID-19 is confirmed. “One [pill] kills the virus, and the second increases the activity of the former, ”explains Shira Doron, a doctor of medical sciences, an infectious disease doctor and epidemiologist at Tufts Medical Center in Boston.
Specifically, the second pill – a low dose of ritonavir – helps slow down a person’s metabolism, so the first pill may work better during treatment, said Keith Longgeli, a spokesman for Pfizer Global Media Relations. “[It] Nirmatrelvir is active in the body for a long time and in high concentrations helps to slow down its metabolism or breakdown to help fight the virus, ”he added.
Dr. The earliest studies of Doron Paxlovid were not limited to Paxlovid’s ability to reduce symptoms, but Longlie’s Good housekeeping “Strong efficacy” was observed in patients who began taking paxlovid within five days of COVID-19 symptoms.
In general, it is understood that Paxlovid helps to reduce the duration of the disease, and in any case, helps to prevent the symptoms of people from moving to the danger zone.
Prescriptions for Paxlovid are increasingly common for people with COVID-19 and symptoms. Current recommendations suggest that anyone with the same risk factor or symptoms of COVID-19 complication may be able to take Paxlovid. Sick people do not need to consult their doctor to get a prescription, as well as a doctor. Doron added that going to the TV is good enough to get antiretroviral treatment early.
What are the possible side effects of Paxlovid?
Although the tendency for long-term side effects of Paxlovid to appear on social media platforms and online community boards has a bitter taste, this temporary side effect is not the biggest concern for health care providers.
“The most serious side effect is Paxlovid’s drug interaction, and it’s important to tell your doctor about every prescription and over-the-counter medication and supplement you are taking.” Dr. Doron emphasizes. A recent FDA information sheet on Paxlovid shows that there are 14 different medications taken at the same time that pose a serious risk to your health and liver. Some of the medications on the list may prompt your caregiver to consider other options – the National Institutes of Health (NIH) has published a complete list of medications that are expected to interact with the individual aspects of Paxlovid.
Officially, there are seven potential side effects of Paxlovid listed by the FDA that your care provider should let you know:
Muscle aches or pains
high blood pressure
The sense of taste has changed
Diarrhea, dizziness and other gastrointestinal disorders
All of these side effects are temporary in nature, and patients may experience one, two, or more unique combinations at any time during Paxlovid treatment. A Pfizer spokesman said the first study on nirmatrelvir had been published New England Journal of Medicine The recorded side effects were similar in both placebo and active treatment groups, suggesting that some of these side effects were simply associated with active SARS-CoV-2 infections.
Although not studied by federal health agencies, there are concerns raised by health care providers about the potential recovery effects associated with Paxlovid in vaccinated individuals. According to a medical pre-release shared in late April, researchers in Boston identified a 71-year-old vaccinated man who had been diagnosed with Paxlovid shortly after being diagnosed with the infection; Within 48 hours, the patient reported asymptomatic and persisted for more than a week. Her symptoms returned on the 9th, but she remained ill for another four days.
The genetic sequence highlighted in the pre-print showed that his initial infection had returned. However, as this is the first piece of documented data on the phenomenon, health officials do not have enough information to say whether this rebound effect is widespread.
What is Paxlovid Mouth? Understanding the bitter taste in your mouth:
According to Dr. Doron, the bitter, almost bitter taste that people feel after taking Paxlovid, has become one of the most common side effects in his patients. “There are several theories, but no one knows why Paxlovid has this negative effect,” he explains. “This has been observed with other drugs.”
According to Longley and other Pfizer studies, both nimatrelivr and ritonavir are naturally bitter – so Paxlovid causes persistent bitterness during treatment. Officially marked dysgeusia Changes in taste perception in the scientific community were noted in one of the Pfizer clinical trials; Approximately 6% of participants in the active treatment group experienced a change in taste, Compared to .3% of a placebo group, Longley tells us.
Unfortunately, medical staff have not been able to find a way to prevent bitterness during treatment for all people who have taken Paxlovid – or have been told that there is a solution to stop the bad taste once you notice it.
If you feel a bitter, foul taste in your mouth while taking the medicine, know that this is completely normal and will go away. “It’s to be expected – I don’t know how long it will last for most,” the doctor said. Doron adds. “It’s all still new.”
Given that there is still active research on paxlovid and other antiviral drugs, developers will be able to find ways to effectively block this temporary discomfort in future iterations of treatment.
Is it safe to take Paxlovid?
Since Paxlovid can be prescribed with a virtual diagnosis, It is very important to disclose existing recipes so as not to pose a serious risk to your health – and also mark existing allergies. Because your primary care provider knows your medical history well, Talk to them directly about adding Paxlovid or other oral antiviral drugs to your COVID-19 recovery high recommended.
In addition to other federal health agencies, the World Health Organization (WHO) has officially recommended Paxlovid “for mild to moderate COVID-19 patients at high risk of hospitalization.” The prescribed side effects of the drug can be depressing, but medical experts have determined that everything is temporary and limited to the planned treatment cycle of the drug, in other words, “Paxlovid mouth” is not something that will affect you forever.
It is clear that the benefits of this effective drug outweigh the temporary side effects for most people diagnosed with COVID-19. “Considering the mostly mild nature [each] As a result of the incident and very few participants, the study was discontinued as a negative reaction[s] does not meet the inclusion criteria as a warning by regulators, ”Longley explains.
Do not be discouraged if your primary care assistant does not prescribe Paxlovid immediately after a positive COVID-19 test; Although safe for most of the population, Paxlovid has the potential to put you at risk for a pre-existing medical condition or prescription. In addition, WHO officials are refusing to take Paxlovid to those who do not currently have symptoms and are not considered at high risk of serious consequences because, according to the group, its “benefits are insignificant.”
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