Summary: Eating green vegetables and adding daily chlorophyllin may help ease symptoms of inflammatory bowel disease, researchers say. Additionally, chlorophyllin supplements may help reduce the risk of death associated with IBD.
A source: APS
According to researchers at the Diabetes and Metabolism Research Center of Sichuan University in China and Cedars Sinai Medical Center in Los Angeles, a chlorophyllin dietary supplement can reduce inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis.
In addition, chlorophyllin significantly reduces death related to IBD, weight loss, diarrhea and hidden blood in the stool, damage to the intestinal epithelium and infiltration of inflammatory cells.
Results published ahead of print American Journal of Physiology-Gastrointestinal and Liver Physiologyand the study was selected as an APS Featured Article for August.
Chronic gastrointestinal diseases such as IBD affect tens of millions of people living in the United States, as the condition has become a global health burden due to the rising cost of treating it.
Although the exact cause of IBD is not fully understood, some contributing factors include stress and environment, lifestyle, and dietary choices such as high consumption of meat or fish.
Chronic inflammation, abnormalities in autophagy — the body’s process of clearing damaged cells to make room for new, healthy cells — and lysosomal stress (an organelle abnormality that causes inflammation) are also linked to the condition.
Current therapy for IBD includes drugs that suppress the immune system (immunosuppressants) and surgery. However, long-term use of immunosuppressive treatment can cause serious side effects, including opportunistic infections and even organ failure.
In this study, scientists found that oral administration of chlorophyllin—a compound derived from the green pigment found in plants—reduced colitis and abnormalities in the intestinal epithelium of mice.
Also, consumption of green vegetables and chlorophyllin may be beneficial for IBD recovery by reducing inflammation and autolysosome flux (a process that uses the lysosome to degrade and remove toxic molecules and organelles).
The green pigment found in these foods and supplements may initiate a nutritional signal to modulate autophagy in cells, which may suppress IBD symptoms.
Researchers believe these findings could lead to less invasive treatments for IBD.
“Consumption of green vegetables or green pigment supplements such as chlorophyllin may help people with inflammatory bowel disease,” said Xiaofeng Zheng, PhD, of Sichuan University and one of the study’s authors.
This is about diet and inflammation research news
Author: Press service
A source: APS
The connection: Press service – APS
Photo: Image is in the public domain
Original research: Open access.
Philip Dahlsbecker et al. American Journal of Physiology-Gastrointestinal and Liver Physiology
Liver devices on a chip: pros and cons of complexity
Physiologically relevant and widely applicable liver cell culture platforms are of great value in drug development and disease modeling.
Organ-on-a-chip systems offer a promising alternative to conventional, static two-dimensional (2-D) cultures by providing relevant signals such as perfusion, shear stress, and three-dimensional (3-D) cell-to-cell. the connection.
However, such devices involve a wide range of complexities in both manufacturing and implementation. In this review, we summarize the key features of the human liver that should be represented in a physiologically relevant liver-on-a-chip model.
We also discuss the various material properties important in the fabrication of liver devices on a chip and summarize recent and current progress in the field, highlighting the various types of devices at different levels of complexity.