Summary: Older mice did not benefit as much when it came to extending their lives from the blood of young mice. However, the lifespan of young mice exposed to the blood of older mice was significantly shortened.
A source: Mary Ann Liebert Inc
A new study in which young and old mice were surgically joined so that they shared the circulation for three months showed that the old mice had little benefit in terms of life expectancy.
However, young mice exposed to the blood of older animals were significantly reduced compared to mice that shared blood with other young mice.
The study was published in a peer-reviewed journal Rejuvenating research.
Heterochronic parabiosis is a research tool used to assess the effects of organ and blood-borne factors in young and old animals. Parabiosis, which is less controlled than direct blood exchange, is a model of blood exchange in two surgically connected animals.
Iryna Pishel, Taras Shevchenko National University of Kyiv and Bienta Ltd., Kyiv (Ukraine, Kyiv) and co-authors used heterochronic parabiosis and isochronous control between young and old mice for three months.
They then isolated the animals and studied the effects of the addition on the blood plasma and the animals’ lifespan.
“The strongest and most interesting result of this study is the significant reduction in lifespan of young mice from the heterochronic parabiotic pairing,” the investigators said.
“These data support our hypothesis that aged blood contains factors that age young animals. “Finding and selectively suppressing the production of aging factors in the body may be a key area of research to extend life,” they concluded.
Editor-in-Chief Irina Conboy, PhD, is a professor at the College of Engineering at the University of California, Berkeley says, “This work clarifies the debated question of whether young blood or old blood governs longevity (Nature 2005, Conboy, et. al.). Do heterochronic parabiosis have long-lasting effects, and if so, is it rejuvenating or aging?
“The work of the Pishel group has determined life expectancy the number of old mice does not increase after parabiosis to young mice. In contrast, young animals mated with old mice had shorter lifespans even after weaning.
“This discovery is important in defining the precise direction of antiaging clinical approaches and providing basic scientific evidence against the potential of young blood factors in the aging body.
“This work is consistent with a previously published report by this group that transfusion of young blood plasma in mice does not prolong their lifespan (Shytikov, Rejuvenating research)”
Importantly, Professor Pischel conducted this basic research as head of the department at Kyiv National Taras Shevchenko University, but wrote as a fugitive from the data collected before the war. Such important researches have been interrupted by the war, and we hope that they will soon be resumed and more progress will be made.
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Author: Kathryn Ruhle
A source: Mary Ann Liebert Inc
The connection: Kathryn Ruhle – Mary Ann Liebert Inc
Photo: Image is in the public domain
Original Research: Open access.
Irina Pishel et al. Rejuvenating research
Three-month heterochronic parabiosis has a negative effect on the life of young animals, but does not have a positive effect on old animals.
Our previous study showed that blood exchange between heterochronic parabionts for 3 months did not rejuvenate the immune system of the old partners. In addition, the young immune system has aged and started to work according to the “old” principle. Does this forced aging affect all body systems in this model?
We examined the levels of corticosterone, testosterone, insulin-like growth factor 1 (IGF-1), insulin and thyroxine in the blood of heterochronic parabionts, but found no significant changes compared to age-matched controls.
Because many data support the potential for rejuvenation of brain, muscle, and other tissues using the heterochronic parabiosis model, as well as conflicting data, we planned to evaluate the overall effect of this long-term blood exchange on the rate of aging of the organism. .
We measured the lives of the animals that were exchanged for blood for 3 months and then weaned. Young heterochronic parabionts had reduced mean and maximum life spans compared to isochronous controls.
Older heterochronic parabionts showed only a slight trend toward an increase in average life span, but it was not statistically significant, and maximum life span did not change compared to isochronous parabionts.
These data support our hypothesis that old blood factors can predispose young animals to senescence. The mechanism of selective suppression of the production of aging factors in the body may be a key research area for life extension.