Benefits, doses and side effects of glutathione

If you want to significantly contribute to your health and well-being, you may want to consider glutathione – commonly referred to as GSH.

“Glutathione is a molecule made up of three amino acids found in every cell of the body. [cysteine, glutamic acid and glycine] They come together to make a simple protein, ”said Nayan Patel, an adjunct and author of the School of Pharmacy at the University of Southern California. Glutathione Revolution: Fighting Disease, Slowing Aging and Increasing Energy. “And what it does is it’s an antioxidant, it slows down all the free radicals before they’re out of your body.”

In fact, Patel calls glutathione “the most important antioxidant in the world” because it is able to neutralize the toxic chemicals we regularly encounter, such as heavy metals, cosmetics and pollution. However, from the age of 25, the body’s ability to produce natural glutathione begins to decline, and these modern environmental stresses further lower our levels.

“When oxidative stress [which is defined as an imbalance that leads to cell and tissue damage] When it is too high in the body, we start to see different diseases: obesity, diabetes, hypertension, heart disease, metabolic disorders – we go to cancer, ”he said.

The good news is that we can increase the level of this antioxidant power in many ways. “Glutathione is naturally found in protein (such as beef and poultry), vegetables (such as kale and spinach), and sulfur-rich cross-shaped vegetables (such as broccoli, cauliflower, and Brussels sprouts),” says Tasnim Bhatia, MD (“Dr”). Taz ”), founder and medical director and author of CentreSpringMD in Atlanta Super Woman RX. He adds that eating foods high in vitamin C, including citrus fruits, kiwis and strawberries, can also increase glutathione levels.

Additionally, this is another option. A randomized controlled trial was published European Journal of Nutrition Glutathione supplements have been found that daily consumption of 500-1,000mg may be effective in increasing GSH storage. Also topical patented antioxidant spray Dr. Patel was formed after many years of clinical research.

“We have found a water-based technology that delivers glutathione molecules directly to blood cells and can be used immediately by the body,” he explains. “I’m on a crusade to change people’s lives.”

Below we highlight the eight health benefits of this master antioxidant.

1. Reduces oxidative stress

              According to an article published in the magazine nutrients, glutathione has been found to be a “promising and exciting” treatment to combat cell and tissue damage. This study showed that GSH has the potential to supplement amino acids (including L-glycine) and micronutrients (including vitamin C, vitamin E and magnesium), as well as certain dietary regimens (vegetarian, Mediterranean diet and DASH diet). Increasing the concentration of glutathione, which in turn slowed the rate of tissue deterioration. “Glutathione reduces oxidative stress in the body and reduces the risk of cancer,” says Dr. Taz.

              2. Helps improve insulin levels

              High levels of GSH can lead to less fat accumulation in the abdomen, which reduces the risk of some types of diabetes, says Dr. Taz. Researchers at Baylor College of Medicine in Houston have combined studies of older people and older mice because both groups suffer from glutathione deficiency, a common side effect of aging. Less than two weeks after the volunteers were instructed to eat foods containing the amino acids cysteine ​​and glycine, such as lentils and sunflower seeds, their ability to burn body fat jumped at an average rate similar to that of an average adult. (Yes, mice had similar results.)

              3. Can reduce the side effects of type 2 diabetes

              The study authors recruited a small group of adults with type 2 diabetes mellitus, as well as those with “severe glutathione deficiency,” and used a dietary supplement called cysteine ​​and glycine for two weeks. Results published in the journal diabetes careThe supplement was found to reduce oxidative damage due to high glucose levels, restoring GSH levels.

              4. Reduces the risk of heart disease

              In an animal study conducted at the University of Michigan Health Systems, researchers gave grapes-enriched diets to rats with hypertension (chronic high blood pressure). After 18 weeks, the authors found that the antioxidants in the fruit “turned on” the antioxidant defense pathways, eventually increasing the activity of genes that enhance glutathione production. In addition, rats had better diastolic function and less dilation of the heart muscle (lower blood pressure readings indicate how much blood pressure the arteries exert with each heartbeat).

              5. Helps the liver function

              Glutathione can be an effective medicine for the liver affected by alcohol abuse, says Dr. Taz. Medical researchers from Italy treated adults with alcoholic or non-alcoholic fatty liver disease with IV drops filled with high doses of GSH. A few months after the end of the test, both groups not only showed a “significant” improvement in bilirubin levels (a substance produced in the liver, in the normal process of destroying healthy erythrocytes that the liver regularly destroys), but also a decrease in malondialdehyde. , a marker of liver cell damage.

              6. Prevents obesity

              “If the body is low in glutathione, environmental toxins are metabolized in adipose tissue, which helps the body retain excess weight,” he said. Patel. According to a study published in the journal Experimental and therapeutic medicineAdults diagnosed with metabolic syndrome – a number of health conditions (e.g., high blood pressure, high blood sugar, high cholesterol, and low waistline) increase the risk of heart disease, diabetes, and stroke. National Institutes of Health – and those who initially tested for high levels of glutathione – showed a significant reduction in body weight and body fat percentage after following a six-month personalized healthy eating plan.

              7. Helps fight autoimmune problems

              “Thus, if glutathione affects all metabolic diseases, it also includes autoimmune conditions,” says Dr. Patel. A study published in the journal Autoimmune reviews In patients living with lupus, an autoimmune disease in which the immune system mistakenly attacks healthy cells and tissues, they found that there is a strong link between oxidative stress and apoptosis – a controlled process of cell death. Decreased glutathione, on the other hand, has been shown to be “closely linked” to cell damage.

              8. Can help fight COVID-19

              Researchers at Baylor College of Medicine compared the blood samples of healthy adults before the pandemic with those hospitalized with COVID-19 at the same age, and showed that patients with the virus (age 21) had significantly higher levels of oxidative stress and oxidative damage. as well as a sharp drop in glutathione levels. Their results were published in the journal antioxidants, We recommend supplementing those tested positive for COVID-19 with a combination of glutathione precursors (previous studies have shown this to improve levels and reduce inflammation) may be an effective treatment. Researchers encourage future research with COVID-19 patients.

              Adverse effects and risks of glutathione

              The FDA (Food and Drug Administration) says glutathione is “generally recognized as safe.” However, the National Institutes of Health (NIH) is important to keep in mind that most supplements contain active ingredients that can cause a reaction.

              One study identified possible interactions between men who received glutathione IV skin drops, including liver problems or infertility, so the FDA warned the public about the dangers of injecting skin lightening agents. Another study (patients were also given GSH and oxidized GSSG) showed that a very small percentage of participants struggled with temporary liver problems or rashes.

              “Most glutathione studies use IV or oral glutathione, and the most commonly used dose can range from 500 milligrams to 2 grams,” explains Dr. Patel. “Because digestion is very poor and it is broken down into different amino acids that can have a profile of various side effects.”

              Dr. People who are sensitive to bald sulphate are said to get rashes from glutathione. Dr. Patel adds that people who use low doses (100 or 175 milligrams) of topical treatment are more likely to develop small rashes that will dissipate quickly “in a short amount of time”. It is recommended that people reduce the dose to meet their needs.

              Of course, if you think you are experiencing the negative effects of glutathione, be sure to consult a medical professional.

              Dietary supplements are products designed to supplement the diet. They are not drugs and are not intended to treat, diagnose, alleviate, prevent or cure disease. If you are pregnant or breastfeeding, be careful not to take dietary supplements. Also, be careful not to give the child supplements unless recommended by their health care provider.

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