An exercise-induced metabolite that suppresses nutrition and obesity

  • Eriksson, KF & Lindgärde, F. Prevention of type 2 (non-insulin dependent) diabetes through diet and exercise. diabetes 34891-898 (1991).

    CAS article Google Scholar

  • Rejeski, WJ et al. Lifestyle changes and mobility in obese people with type 2 diabetes. N. Engl. J. Honey. 3661209–1217 (2012).

    CAS article Google Scholar

  • Stampfer, MJ, Hu, FB, Manson, JE, Rimm, EB & Willett, WC Basic prevention of coronary heart disease in women through diet and lifestyle. N. Engl. J. Honey. 34316–22 (2000).

    CAS article Google Scholar

  • Helmrich, SP, Ragland, DR, Leung, RW & Paffenbarger, RS Decrease in physical activity and insulin-dependent diabetes mellitus. N. Engl. J. Honey. 325147–152 (1991).

    CAS article Google Scholar

  • Ravshani, A and others. Risk factors, mortality and cardiovascular disease in patients with type 2 diabetes. N. Engl. J. Honey. 379633–644 (2018).

    Article Google Scholar

  • Sanford, JA et al. Molecular Modifiers of the Physical Activity Consortium (MoTrPAC): Map of Dynamic Responses to Exercise. cell 1811464–1474 (2020).

    CAS article Google Scholar

  • However, K. Molecular choreography of intensive training. cell 1811112–1130.e16 (2020).

    CAS article Google Scholar

  • Morville, T., Sahl, RE, Moritz, T., Helge, JW & Clemmensen, C. Profiling Plasma metabolome resistance exercises and endurance exercises in humans. Cell Rep. 33108554 (2020).

    CAS article Google Scholar

  • Lewis, GD et al. Metabolic signs of exercise in human plasma. Sci. translation Med. two33ra37 (2010).

    Article Google Scholar

  • Roberts, LD, et al. β-aminoisobutyric acid induces the brown color of white fat and liver β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 1996–108 (2014).

    CAS article Google Scholar

  • Stanford, KI et al. 12,13-diHOME: Lipokine caused by exercise increases skeletal muscle fatty acid uptake. Cell Metab. 271111–1120.e3 (2018).

    CAS article Google Scholar

  • Reddy, A., et al. The secretion of pH-gate succinate regulates muscle remodeling in response to exercise. cell 18362–75.e17 (2020).

    CAS article Google Scholar

  • Yuan, Y., et al. Exercise-induced α-ketoglutaric acid promotes muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J. 39e103304 (2020).

    CAS article Google Scholar

  • Klein, AB et al. Pharmacological but not physiological GDF15 promotes nutrition and exercise. nat. the total 121041 (2021).

    ADS CAS article by Google Scholar

  • Green, HJ & Fraser, IG Differential effects of exercise intensity on blood uric acid concentration. Med. Sci. Sports training 2055–59 (1988).

    CAS article Google Scholar

  • Schranner, D., Kastenmüller, G., Schönfelder, M., Römisch-Margl, W. & Wackerhage, H. Metabolite concentration after a fight in human exercise: a systematic review of exercise metabolomics studies. sport Med. clear 611 (2020).

    Article Google Scholar

  • Gaffney, B. & Cunningham, EP Assessing the genetic predisposition of racehorses to purebred horses. nature 332722-724 (1988).

    ADS CAS article by Google Scholar

  • Hagenfeldt, L. & Naglo, AS New conjugated urine metabolites with secondary type maple syrup urinary tract disease. Chim Clinic. Minutes 16977–83 (1987).

    CAS article Google Scholar

  • Bottesini, C., Tedeschi, T., Dossena, A. & Sforza, S. Enzymatic production and degradation of non-proteolytic aminoacyl derivatives derived from cheese. amino acids 46441–447 (2014).

    CAS article Google Scholar

  • Сгарби, Е. Microbial origin of non-proteolytic aminoacyl derivatives in long-ripened cheeses. Food microbiol. 35116–120 (2013).

    CAS article Google Scholar

  • Jansen, RS, et al. Do not-lactoil-amino acids are ubiquitous metabolites derived from the reverse proteolysis of lactate and amino acids by CNDP2. process Natl Acad. Sci. USA 1126601–6606 (2015).

    ADS CAS article by Google Scholar

  • Sharma, R. and others. Rotational markers of NADH-reductive stress are associated with the severity of mitochondrial disease. J. Clin. Invest. 131e136055 (2021).

    CAS article Google Scholar

  • Tabula Muris Consortium. Single-celled transcriptomy of 20 organs of the mouse a Tabula Muris. nature 562367–372 (2018).

    ADS CAS article by Google Scholar

  • Locke, AE et al. Genetic studies of body mass index provide new insights into the biology of obesity. nature 518197–206 (2015).

    CAS article Google Scholar

  • Рингхолм, С. PGC-1α is required to regulate UCP1 caused by exercise and exercise training in the white fat tissue of the mouse. PLoS ONE 8e64123 (2013).

    ADS article Google Scholar

  • Kim, YJ, Kim, HJ, Lee, WJ & Seong, JK Comparison of metabolic effects of mouse model running and cycling exercises. laboratory anime. Res. 361–8 (2020).

    Article Google Scholar

  • De Wolf, CJF and others. cGMP transport via vesicles from human and mouse erythrocytes. FEBS J. 274439–450 (2007).

    Article Google Scholar

  • Smith, CA et al. XCMS: Processing of mass spectrometric data to create a profile of the metabolite by aligning, matching and identifying nonlinear peaks. Anal. Chem. 78779–787 (2006).

    CAS article Google Scholar

  • Agudelo, LZ et al. Skeletal muscles modulate the metabolism of PGC-1α1 quinureine and withstand stress-induced depression. cell 15933–45 (2014).

    CAS article Google Scholar

  • Coxon, JP et al. Relationship between GABA concentration and lactate levels in the sensorimotor cortex after high-intensity exercise. J. Physiol. 596691–702 (2018).

    CAS article Google Scholar

  • Human Energy Requirements: FAO / WHO / UNU Expert Advisory Report (FAO, WHO, UNU, 2005).

  • Sanjana, NE, Shalem, O. & Zhang, F. Improved vectors and genomic libraries for CRISPR screening. nat. Methods 11783–784 (2014).

  • Leave a Comment

    Your email address will not be published.