A person who eats sea water eliminates the signs of old age

Summary: Supplementing the diet with ascidiacea or seawater eliminated some key signs of aging in mouse models.

A source: Xi’an Jiaotong-Liverpool University

If you ever look in the mirror, see that your hair is gray and wrinkled, or forget the name of a close friend, you will be forgiven for wanting anti-aging pills, or even anti-aging pills.

New research shows that this is not a fantasy. Researchers at Xi’an Jiaotong-Liverpool University, Stanford University, Shanghai Jiao-tung University and the Chinese Academy of Sciences have reported that supplementing the diet with Ascidiacea marine organisms, also known as seafood, will eliminate some of the key symptoms. animal-type aging.

Seawater can be eaten raw and is found in Korean food (there) meonggeor 멍게) and Japan (today is, or ホ ヤ). These marine organisms contain substances called plasmalogens, which are important for the processes in our bodies.

Plasmalogens are found throughout the body in a natural way, especially in the heart, brain and immune cells, but their number decreases as we get older. This loss is also characteristic of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease.

To study whether increasing plasmalogen levels could reverse the effects of aging, the researchers studied the effect of plasmalogen supplementation on the diet of elderly mice.

They found that the supplements had a profound effect on the reading ability and physical characteristics of these mice.

The study’s author, Professor Lei Fu, states: “Our research shows that plasmalogenes can not only stop cognitive decline, but also reverse cognitive impairment in the aging brain. In addition, plasmalogen-fed mice develop new black hair that is thicker and shinier than non-plasma-fed mice.

This study, for the first time, details how plasmalogens affect the aging brain.

make new connections

The effects of plasmalogen on reading and memory were tested by training mice to use a swimming pool that contained the Morris Water Labyrinth, a playground. Mice generally do not like to swim, so after five days of training, they remember where the platform is and swim straight into it. However, older mice take longer to find a platform after the same amount of exercise.

Surprisingly, when fed with plasmalogens, older mice act like young mice and find the platform faster than the control group of older mice who were not given supplementation.

To find the cause of the improvement in plasmalogen-fed mice, the researchers carefully examined changes in the brain. They found that the number and quality of synapses between neurons were higher in mice fed plasmalogen than in older mice without supplements.

Synapses are a key part of our neural networks, so they are very important for learning and memory. Our synapses are very plastic in childhood, but their number decreases, worsens with age and in neurogenetic diseases, leading to cognitive impairment.

Therefore, in this study, the diet of elderly mice fed a plasmalogen supplement showed greater potential for learning new skills and building new neural networks than for mice with an incomplete diet. This suggests that dietary plasmalogens can stop age-related deterioration of synapses.

Another feature of aging and inflammation of the brain, which is considered a significant factor in neurodegeneration. Excessive inflammation can adversely affect cognitive ability, as the brain’s immune system becomes overactive, self-igniting, attacking neurons, and preventing synapses from functioning properly.

Seawater can be eaten raw and is found in foods from Korea (called meong or 멍게) and Japan (hoya or ホ ヤ). Credit: Jpatokal

In this study, inflammation in elderly mice was significantly reduced in plasmalogen compounds compared with those on a normal diet, which provided an explanation for why they performed better in reading and memory tasks.

Possible ways of action

Although it is still unknown how significant changes in dietary plasmalogen compounds can cause learning and memory, Professor Fu ponders possible ways of action.

“We found that plasmalogens significantly increase the number of molecules that help neurons and synapses in the brain to grow and develop. This suggests that plasmalogens promote neurodegeneration.

“There is also growing evidence that plasmalogens have a direct effect on the structural properties of synapses. Plasmalogens can increase the fluidity and elasticity of synaptic membranes and affect the conduction of impulses between neurons. ”

In addition, Professor Fu explains that plasmalogens can have an indirect effect on the brain.

“Some studies have shown that dietary plasmalogens affect gut microbiota. It has been widely reported that the connection between the organisms in our gut and our brains affects neurodegeneration. Plasmalogen may be responsible for this connection, which led to improved learning and memory observed in this study.

Professor Fu is so convinced of the results of this study that he takes a plasmalogen supplement every day.

“For the first time, we are demonstrating that plasmalogen supplements may be a potential intervention strategy to stop neurodegeneration and promote neuroregeneration.

See also

This shows that someone is pouring a glass of milk

“Oral administration of plasmalogens may be a possible therapeutic strategy to improve cognitive function in the elderly.”

So, a pill that will keep you young may not be a realistic recommendation if it contains seawater.

It’s about diet and aging research reports

Author: Cat Diamond
A source: Xi’an Jiaotong-Liverpool University
The connection: Cat Diamond – Xi’an Jiaotong University of Liverpool
Photo: Photo by Zhpatokal

Original study: Open access.
“Plasmalogens eliminate synaptic defects associated with aging and microglia-mediated neuroinflamation in mice,” Jinxin Gu et al. Boundaries in Molecular Biology


Abstract

Plasmalogens eliminate age-related synaptic defects and microglial neurosensitivity in mice

Neurodegeneration is a pathological condition in which the nervous system or neuron loses its structure, function, or both, leading to progressive neuronal degeneration. Growing evidence suggests that a decrease in plasmalogens (Pls), one of the brain’s major lipids, may be associated with several neurodegenerative diseases, including Alzheimer’s disease (AD).

Plasmalogens are many members of ether-phospholipids. Approximately 1 in 5 phospholipids are plasmalogens in human tissue, which are especially enriched with brain, heart and immune cells. In this study, we used a 2-month Pls intragastric control regimen in C57BL / 6J mice aged 16 months of age.

It should be noted that older mice fed Pls showed better cognitive ability, and their appearance showed thicker and shinier body hair than older control mice.

Transmission electron microscopy (TEM) data show that 2-month-old Pls supplements surprisingly alleviate age-related hippocampal synaptic losses and also produce synaptogenesis and synaptic vesicles in the elderly brain.

Further analysis of RNA sequencing, immunoblotting, and immunofluorescence confirmed that plasmalogenes dramatically improved both synaptic plasticity and neurogenesis in the hippocampus of elderly mice. In addition, we showed that treatment with Pls inhibited age-related microglia activation and reduced neuroinflammation in the mouse brain.

These findings show for the first time that Pls management may be a potential intervention strategy to stop neurodegeneration and promote neuroregeneration.

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