A neurobiologist explains what happens when Dexie drinks at night

Like other ADHD drugs such as Adderall in the U.S., dextroamphetamines began as a research drug in Australia.

Suffering from a problem known to many as “Dexi,” the sleepless student traveled late into the night, taking small pills, hoping for a burst of energy and hyperfocus.

But in recent years, dexterity seems to have moved from classrooms and clubs as an alternative to things like MDMA, cocaine and ketamine. First, they are cheaper, and second, they are easier to obtain.

Little has been said about the potential side effects of dexterity energy, which allows its users to stay awake in the morning, encourage and relax.

To find out, VICE spoke with Dr. Andrew Lawrence, a senior researcher at the Flori Institute of Neurology and Mental Health at the University of Melbourne.

Dr. Lawrence’s main area of ​​research is addiction, mainly alcohol, but he already has experience with nicotine, opioids, stimulants and amphetamines.

So that’s really what is dex?

“Only dextroamphetamine [the proper name for dexies] and methylphenidate [Ritalin] There are two main treatments for ADHD, ”said Dr. Lawrence VICE.

“[ADHD] partly due to the release of unregulated catecholamines [chemicals that the brain and nerves produce]Dopamine, especially hyperactivity and inability to concentrate.

According to Lawrence, the action of chemicals such as dopamine is stopped (or stopped) in two ways: through metabolism and / or when they are transported back to the nerve terminal in the brain. This is a process that stops overstimulation.

“Amphetamines reverse this transport process, thus actively releasing more neurotransmitters into synapses and preventing them from being taken back to the brain. Thus, the only mechanism to stop the drug from being on board is a slower mechanism.

For people with ADHD, this process reduces hyperactivity and increases concentration.

“You did not predict that it would have such an effect. But, paradoxically, so be it. So it works very efficiently. They work almost immediately. For example, you don’t need time to be on board to use antidepressants to achieve a positive result. “

What happens when people without ADHD use it?

In fact, the answer is simple: dexterity helps you feel healthier and hyperactive by increasing “feeling good” chemicals.

“In people without ADHD, dextroamphetamine does the same: it increases chemicals like dopamine. So it works as a stimulant in people who use it for relaxation, because what you’re doing dramatically increases dopamine, norepinephrine and serotonin levels in the brain and body.”

What happens when dexterity is mixed with alcohol?

“If you take dextroamphetamines and alcohol together, as we said, dexterity is stimulant, and alcohol is depressive. At the behavioral level, they act against each other to some degree, ”said Dr. Lawrence.

Lawrence cited an example from a 2012 study in which drunk drivers were tested with and without dextroamphetamines in their systems.

“Thus, alcohol consumption within three hours after drinking led to an increase in risk behaviors, impaired monitoring, and decreased attention and reaction time. The stimulating effect of dextroamphetamines at 10 milligrams [a regular dose is 10-20mg every 4 hours] It was not enough to overcome the harmful effects of alcohol. ”

“So it’s not good to use two things at the same time. You will continue to show risky behaviors, and your health will continue to deteriorate. “

It also depends on how much alcohol you drink. If you are tired or slow or do not drink alcohol, it will take a lot of effort to recover.

What about herbs?

Like alcohol, dexterity can resist weeds to some degree. However, there may be side effects.

“You can see the psychotic side effects because some people get psychosis from both stimulants and marijuana use, especially long-term marijuana use,” said Dr. Lawrence.

“So, if you’re one of those sensitive people, combining the two makes it even more possible.”

When asked why some people may prefer dexin over other medications, Dr. Lawrence says it’s hard to say. In fact, it depends on the person.

“Impact may depend on the time course, subjective experience, availability, cost – many factors.”

What about long-term risks? Should a person rushing out on a Saturday night with a bag or two in his bag be worried?

Now this is the scary part that most people don’t want to hear. But the bad news is: it doesn’t matter here.

“In terms of side effects, if you have amphetamines, they mimic the effects of norepinephrine and adrenaline in your system,” said Dr. Lawrence.

“So it raises your blood pressure, it increases your heart rate, and you are more likely to have heart problems like vasospasms and arrhythmias. If you do that for a long time, you are more likely to have things like a stroke.”

Dr. Lawrence says when it comes to addiction, it really relies on your sensitivity. For some people, this is not a problem. For others, it may be.

“In fact, most people who experiment with drugs do not become addicted. However, there is a significant minority that has become dependent. There are a number of reasons for this, some genetic, some physiological, and some behavioral. And some we just don’t know.

“So it’s like playing Russian roulette, because you don’t know if you’re too addicted or not.” And when you find out, it’s probably too late. ”

And Dr. Lawrence suggests using it for relaxation?

No, not at all.

“I don’t recommend using them for recreation,” he said.

“I want to say that there are a number of issues around this. There are possible legal issues with the use of the controlled substance for recreational purposes. Single use can be harmful. Of course, repeated use can be harmful.

“I’m not from any party, but I wouldn’t recommend it.”

Although Dexi clubs are known for their soothing and energizing effects, the results for the body are not as good as when some medications are used in conditions other than the initial relaxation. However, it is unlikely to stop most people.

The main thing is to be responsible in any party situation, to take it slowly and listen to your body.

So you have. Dexies: They’re good for dealing with something that was literally created for treatment, and a little sketch of the other.

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